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1 Cigarette smoking can also lead to other respiratory cancers such as oropharynx, larynx, trachea, and bronchus

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These toxic and carcinogenic ingredients induce tumorigenesis in the GI tract through several possible mechanisms, including the activation of nicotinic acetylcholine receptors (nAChRs), the formation of DNA adducts, stimulation of tumor angiogenesis, the involvement of immune response and others (Fig