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Nicotines vasoconstrictive effects limiting circulation during arousal

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88 In addition, the autoimmune response to elastin fragments, which develops after chronic tobacco smoking, points to a certain immunogenic activity of elastin-degradation products on DC-mediated adaptive immunity

The concentration of hemoglobin-bound CO (CO-Hb) is intermittently higher in the blood of smokers compared to non-smokers, at levels usually below 10% that are well below those typically associated with the well-documented clinical or epidemiological toxicity of CO 7,8,9