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CYP1A2, 2A6, 2C9, 2D6, 2E1, and 3A4 isoforms also play a role in the metabolism of bupropion, but to a lesser extent (Connarn et al., 2015)

Note that PAFs have also been estimated using an indirect approach, with the level of lung cancer mortality being used as a measure of the maturity of the epidemic in populations, with relative risks from some reference study being scaled accordingly.7 16 The GBD Study previously used the indirect method26 but switched to the direct method a few years ago

Phototoxic reactions have been reported in 11% of patients, and are more frequent in those with light skin phototypes (I and II).11 They are characterized by extensive pruritic erythema that generally reaches maximum intensity after 48 to 72hours and, unlike PUVA-induced acral blisters, necessitates interruption of treatment.3 The presence of sunburn cells in histology is characteristic

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