According to the evolutionary and sequence diversity, microsomal GSTs have been identified to be the integral membrane proteins and are known as M embrane- A ssociated P roteins in E icosanoid and G lutathione M etabolism (MAPEGs)
According to Rysz and colleagues, as CKD progresses, protein-bound uremic toxins, such as IS, p-CS, p-cresyl glucuronide, and indole-3-acetic acid (IAA), gradually accumulate
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doi:10.1016/j.neuroimage.2013.01.045 104a
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