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In an emailed statement, the San Francisco department of public health said it recognized the impact of the crisis, and is working to expand substance use treatment options and overdose prevention efforts

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Although previous studies have shown that the lipophilic compounds present in CSE induce mitochondrial abnormalities in submerged-cultured airway epithelial cells [4, 31], we cannot exclude that exposure to gaseous phase cigarette smoke in ALI cultures has a more pronounced effect on mtDNA methylation