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HER2 transmembrane domain (TMD) mutations (V659/G660) that stabilize homo- and heterodimerization are rare oncogenic drivers in lung adenocarcinoma that respond to afatinib

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Despite, not having the dominant role in cisplatin resistance, ABC proteins, such as ABCG2, ABCC2, ABCA1, and ABCC1, transport a wide variety of chemical compounds in an ATP-dependent manner and play an important role in cisplatin resistance in diverse cancers 41,45,46,47

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