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Methods Overall study design This open-label, randomised, crossover, clinical study received favourable opinion (equivalent to ethics approval) from the Office for Research Ethics Committees Northern Ireland (ORECNI) Health and Social Care Research Ethics Committee A (reference number 21/NI/0144) prior to study commencement

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This leads to the release of apoptogenic factors, such as cytochrome c and SMAC/DIABLO into the cytoplasm

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