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SAM is the universal methyl donor for DNA methylation, histone methylation, and hundreds of other methylation reactions that regulate gene expression

doi:10.1136/practneurol-2014-001071

Option 1: Consult with a doctor asynchronously about B12 shots If youre interested in buying B12 injections you can administer at home, you dont even need to book a telehealth appointment (we know youre busy)

As summarized in the same 2013 review, the pre-specified primary endpoint for statistically significant weight change across the dose range and study duration was not met, even as the safety and tolerability picture held [7]

Can B12 be given subcutaneously at all, or do you need a different method

Some people may experience skin sensitivity, redness, dryness, or irritation with topical copper peptides