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Moreover, age of smoking ( = 0.16, P = 0.21), cigarettes per day ( = 0.08, P = 0.05), smoking cessation ( = 0.06, P = 0.18), smoking initiation ( = 0.01, P = 0.61), and alcohol consumption ( = 0.08, P = 0.20) indicated no significant association with the metabolic ratio of clozapine and norclozapine concentration (Supplementary Table 8)

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The article does mention problems with e-cigarettes, such as toxic chemicals like formaldehyde, acetaldehyde and acrolein, metallic particles from the devices heating element, and free radicals in the vapor

Nicotine from cigarettes is metabolized by the body into cotinine

The products are imported from the neighboring states of Rhode Island and New Hampshire, where theyre still legal