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Elevated NNMT expression has been observed in adipose tissue of animals with insulin resistance, and modulation of this enzyme has been shown to influence weight and metabolic function in preclinical models

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DMF mediates NRF2-dependent and independent mechanisms on TSS pathway CBS activation DMF activates NRF2, the master regulator for the antioxidative stress response, to regulate the expression of proteins involved in iron hemostasis, and GSH synthesis such as HMOX1, NQO1, FTH, FTL, SLC40A1 in a variety of cellular systems 37

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TMBIM6 prevents VDAC1 multimerization and improves mitochondrial quality control to reduce sepsis-related myocardial injury