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doi: 10.15585/mmwr.mm7244a1 20

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Clinical data have shown that IL-6 serum levels from patients with colorectal cancers are significantly increased and positively correlate with tumor load, including tumor size and liver metastases (98)

While genetics can play a role in hyperpigmentation, other factors such as sun exposure, hormones, inflammation (from eczema or contact dermatitis) or injury can also be responsible

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