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doi: 10.3389/fmed.2025.1538194 Received 20 December 2024 Accepted 22 April 2025 Published 09 May 2025 Volume 12 - 2025 Edited by Claudia Fiorillo, University of Florence, Italy Reviewed by Sabina Galiniak, University of Rzeszw, Poland Juan Luis Santiago, Poland Universitario de Ciudad Real, Spain Hiroki Satooka, Shiga University of Medical Science, Japan Jie Zhang, Kunming University of Science and Technology, China Updates Copyright 2025 Luo, Hu, Zhou, Zhang, Wu and Sun

F., Soares-da-Silva, P., Carvalho, C

Of the remaining 45 articles, 6 full texts could not be retrieved and 14 were excluded as they were out of scope

mTORC1 promotes protein synthesis and cell growth by phosphorylating S6K1 and 4E-BP1, whereas mTORC2 further phosphorylates AKT, resulting in the formation of a positive regulatory loop (Popova and Jcker, 2021)

One study found increased density of microglia in the white matter of the forebrain, whereas an earlier study found increased density in gray matter from the entire mouse brain (Lawson et al., 1990

Furthermore, in a phase 2 trial in people with MASLD, 24 weeks of pemvidutide resulted in a relative reduction in liver fat content up to 76% with the 2.4 mg dose vs