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Severity of Toxicity and Exposure As previously noted, the severity of CO poisoning is dose-dependent, meaning that it is related to the concentration of CO in inspired air and the duration of the exposure
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Smoke exposure leads to significantly more AIF and EndoG nuclear translocation in HBE cells from smokers than non-smokers
They informed both their spouses, who briefly objected, until Rand "sp[u]n out a deductive chain from which you just couldn't escape", in Barbara Branden's words, resulting in her and O'Connor's assent
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Importantly, this higher humidity of the smoke and its cooled down nature facilitates deeper inhalation potentially increasing the side effects of using hookah [2]
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