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In vitro toxicity All products were extracted with dimethyl sulfoxide (DMSO) using an ultrasonic homogenizer, filtered, and stored at 80 C prior to assays

Positive media representations of SLTs and their portrayal as an alternative to cigarettes can shape public perception, influencing individuals to perceive these products as attractive and potentially safer alternatives

The risk of death was reduced by 41% for overall mortality HR (95%CI): 0.59 (0.39, 0.89), and 74% for death from cancers HR (95%CI): 0.26 (0.08, 0.83) after ten years or longer of cessation

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Crabol et al., 2016

There are two main types of smokeless tobacco: Chewing tobacco, which is available as loose leaves, plugs (bricks), or twists of rope