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The changes that occur in the brain as a result of this cycle creates a dependence on nicotine because your body is used to having the nicotine in your system, which then becomes an addiction that can be difficult to break

It is difficult to predict how long a middle-aged smoker, for example, will continue before quitting, because smoking careers are highly dependent on the age at initiation, the quantity smoked, and the presence of nicotine dependence

However, smoking can cause a patient to over-bleed or clot too quickly

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I fielded questions like, "Is that a real corn cob pops?" To which off course I had plenty of snarky retorts, like, no, I couldnt afford the real thing, its made of paper

Interestingly, Ouzounova et al