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Both the GIPR and GLP1R are expressed in the central nervous system, wherein receptor activation produces anorectic effects enabling weight loss

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Kisspeptin Kisspeptin has a more indirect effect on local immune tone, primarily regulating the reproductive hormone axis via stimulation of GnRH release

Instead, it supports melanin balance from the inside by shifting melanin production pathways under certain conditions, while also calming oxidative stress that triggers pigmentation

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DOI: 10.1038/s41467-017-01114-1 Formulation strategies for therapeutic peptide stability pH, ionic strength, co-solvency