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SIRT1 can function as p53 deacetylase that blocks p53-dependent pathways, thereby regulating cell-cycle and inactivating apoptotic process [91]

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Reducing the number of people who experiment with cigarettes or certain other combusted tobacco products who then transition to regular use of these products would prevent severe adverse health consequences of long-term smoking at the individual level and result in public health benefits at the population level, according to the FDA

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