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In the cells exposed to nicotine-free vape fluid, the team identified an unusual abundance of a particular protein called ARF6, which looks to be responsible for lung tissue damage in the lab

In the aforementioned study exposing human gingival fibroblasts to CS condensate or to nicotine-rich or nicotine-free e-vapour condensates [29], the detrimental effects were greater in cells exposed to nicotine-rich condensate than to nicotine-free condensate, suggesting that the possible injurious effects of nicotine should be considered when purchasing e-refills

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Smokers also have higher rates of pancreatic cancer