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This drop has been predominantly driven by e-cigarettes, says Harris-Clarke

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171 GWAS in major populations consistently highlight urate transporter genes as pivotal loci influencing serum uric acid levels, 138,139 notably SLC2A9 (GLUT9) and SLC22A12 (URAT1), involved in urate reabsorption from urinary filtrates

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Secondly, smoking cessation intention due to the assumed GWLs on cigarette package was just the attitude of smokers but not the actual behavior change, which impeded the observation of real effect, so implementing an intervention and follow-up study would be a major step forward to evaluate the actual effect of GWLs as tobacco control measure