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Upregulating miR - 195 represses Smad7 gene expression, which can aggravate inflammation through the inhibition of the TNF- signal pathway [177]

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Its exact composition varies, and depends on matters such as user behavior

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A recent case-control study in the United States of nearly 5000 lung cancer cases and more than 27000 controls showed that dual users of CCs and ECs had a fourfold increased risk of lung cancer compared with exclusive CC smokers 17