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Glucagon signals satiation to the central nervous system via the hepatic branch of the abdominal vagus nerve, as vagotomy or lesions in the nucleus tractus solitarius (NTS) in the brainstem prevent glucagons inhibiting effect on feeding [78, 81, 82]

Lipids Health Dis 19:214

Some potential risks of skin whitening include: Skin irritation or itching Redness Uneven skin tone Squamous cell carcinoma Skin thinning Acne breakouts Increased sensitivity to sunlight Liver, kidney, or nerve damage Blue-black pigmentation due to ochronosis disorder

Once activated, NF- stimulates the transcription of cytokines (IL-1, IL-6, IL-8, and TNF-), but also of NADPH-oxidase, all of which favor the production of ROS

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10.1038/s41467-024-45605-4 188 YeJ.WuM.HeL.ChenP.LiuH.YangH