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Based on these findings, Eisai conducted a Phase 2/3 trial (NCT00444613) in Japan to evaluate the safety and efficacy of ultrahigh-dose methylcobalamin injections in 373 adults whose ALS symptoms began up to three years before enrollment

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Two recent meta-analyses that pooled data from patients with end-stage renal disease found no benefit of B-vitamin supplementation on stroke outcomes (34, 35)

doi:10.1097/MAO.0000000000002635