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Patients with severe obesity and multiple weightrelated comorbidities who have not achieved sufficient weight loss with lifestyle measures alone and either are poor candidates for bariatric surgery or prefer pharmacologic options

doi: 10.1038/s41593-024-01764-7 353 TufailY.CookD.FourgeaudL.PowersC

the coupling reactions may be monitored by Kaiser test

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Eating pace matters considerably

[2] The lower headline number in REDEFINE 2 than in REDEFINE 1 is the expected pattern weight loss is typically smaller in populations with type 2 diabetes and is a good reminder that a trials population matters as much as its drug