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This could explain why the number of poison-center calls related to e-cigarettes has increased in recent years, rising from one instance in 2010 to 215 in 2014

1 Background Smoking remains one of the most significant public health challenges worldwide, persisting as a common habit despite the well-documented risks associated with tobacco use

These include raw finishes, subtle washes and exposed seams

Tanaka et al., Caffeine Induces Cardiac and Other Malformations in the Rat, American Journal of Medical Genetics, supplement, 1987:3:43343