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It says a slower escalation than the standard schedule can reduce dose-limiting nausea without compromising efficacy, and that this is particularly relevant for people with baseline gastrointestinal sensitivity

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485 Additionally, overexpressing ABCB8, a mitochondrial protein that promotes iron export, reduces both mitochondrial ROS and iron, improving DOX-induced cardiomyopathy

Renal adverse events are most commonly associated with severe GI losses

DOI: 10.1016/j.neurobiolaging.2007.06.012 86