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This review was developed by a joint task force of the Italian Society of Pediatric Gastroenterology Hepatology and Nutrition (SIGENP) and Italian Society of Pediatric Neurology (SINP) to identify relevant current issues and to propose future research directions on pediatric CVS

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Elevated beta-glucuronidase levels often result in higher levels of proliferative estrogen metabolites such as 4-OH Estrone and 16A-OH Estrone and negatively skew important ratios such as 2-OH (E1 + E2)/16a-OH E1, which is believed to be an independent risk factor for breast cancer

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For mitochondrial metabolites, the number of mitochondrial metabolites individually regulated by principal drug, assistant drug, and complement drug were 4, 1, and 0, respectively

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