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Nat Rev Immunol 3 , 733744 (2003)

Furthermore, enhancing PI3K/Akt/mTOR signalling and restoring BDNF expression represent promising neuroprotective strategies that warrant further preclinical and clinical investigation [41,48]

Dysregulation of the critical developmental pathwaysincluding sonic hedgehog (Shh) signaling (Echelard et al., 1993

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The entire dose enters circulation immediately, overwhelming peptidase capacity momentarily before rapid enzymatic degradation and renal filtration eliminate the compound