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The peptide spreads into the circulation and does five things nearly simultaneously: it drives insulin secretion from pancreatic beta cells, suppresses glucagon from alpha cells, slows gastric emptying, and sends satiety signals to the hypothalamus and brainstem, telling the brain the meal is enough

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Many patients begin to see changes within the first month, with steady improvements as treatment continues

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Semaglutide and tirzepatide are very similar medications, but there are a few important differences, says Dina Peralta-Reich, MD, director of New York Weight Wellness Medicine