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The three non-coded amino acid substitutions serve critical functions: Aib2 provides stability against dipeptidyl peptidase-4 degradation, Aib20 optimizes GIP receptor activity and pharmacokinetic properties, and alpha-methyl-L-leucine at position 13 enhances receptor binding selectivity[2]

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Yang T et al (2016) A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth

1 Antibiotic resistance of bacterial pathogens also affects treatment progress, as resistant infections can compromise life-saving procedures such as chemotherapy, surgeries, and organ transplantation

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