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Its formation is catalysed by UGT1A4
Predicted physicochemical properties supported its hydrophobic character and oral bioavailability, suggesting it is a metabolically stable and BBB-permeable molecule [2]
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1b, c), supporting that the observed morphine-induced constipation in mice does not result from altered food or water consumption
Mol Microbiol 112:12841307 Smith CM, Baker RE, Proulx MK, Mishra BB, Long JE, Park SW, Lee H-N, Kiritsy MC, Bellerose MM, Olive AJ et al (2022) Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice