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The patent relates to the use of antibodies which specifically bind IL-1 to reduce various sequelae of ischaemiareperfusion injury to the central nervous system

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[4] [10] Data from a phase 2 trial published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated that gastrointestinal side effects were among the most commonly reported adverse events with retatrutide, particularly at higher doses

However, excessive NFE2L2 activation may also promote intracellular cysteine accumulation, which can react with sugars to form adducts that impair cell proliferation 163

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