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Young people in their late teens and early 20s might also be at elevated risk, neuro-developmentally speaking, of becoming addicted to nicotine

34 It is probable that peer influences both interact with and are compounded by a host of other predictive factors: 35 selection and socialisation processes can operate independently, but may also have reciprocal effects

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Upregulation of this pathway can lead to overactivation of mitophagy, affecting disease progress through multiple mechanisms, including disrupting energy metabolic balance, inducing programmed cell death, and exacerbating oxidative stress and inflammation through excessive mtROS production (Mizumura et al., 2014

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