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Blunted or impeded therapeutic response to vitamin B12 may be due to such conditions as infection, uremia, drugs having bone marrow suppressant properties such as chloramphenicol, and concurrent iron or folic acid deficiency

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17 These unique findings also highlighted a previously perceived, however poorly understood, interdependence between mucosal epithelium and overlying mucus layers, which collectively maintain the integrity of the mucosal barrier against luminal antigens (Figure 2)

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