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Participants received orforglipron at doses of 6, 12, or 36 mg (which correspond to the current 5.5, 14.5, and 17.2 mg maintenance doses) or placebo, alongside diet and exercise counselling, for 72 weeks

The biggest drops in obesity were reported in the 40-49 and 50-64 age groups, which were also the groups that reported the highest usage of GLP-1 medications in the most recent Gallup surveys

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[PubMed: 11856796] 191

consequently, less is known about the settings where there is an overabundance of NADH reducing equivalents, termed reductive stress

doi: 10.1186/s12929-020-00703-5 283 TuW.WangH.LiS.LiuQ.ShaH