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doi:10.2147/DDDT.S82030 17

One of the most interesting features of one carbon metabolism is that reaction velocities are often affected not just by substrate and product concentrations and enzyme activities but also by the concentrations of substrates in distant parts of the reaction network that act as allosteric activators or inhibitors of the enzyme

In selenium therapy, this could involve adjusting Se dosages based on the patients genetic makeup, which influences how they metabolize and respond to Se