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It should be noted that higher dosages of vitamin B12 may be necessary when treating this population
Vitamin B 12 can also be absorbed by passive diffusion, but this process is very inefficient only about 1% to 2% of the oral vitamin B 12 dose is absorbed passively (2)
Published studies primarily focus on its interaction with enzymatic and metabolic pathways rather than endocrine signaling systems
Individuals with significant kidney impairment might be advised to use alternative forms to cyanocobalamin as a precautionary measure, though evidence of clinical harm at standard supplementation doses is lacking
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