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196-198 Neramexane, an investigational NMDA blocker, was found in a randomized placebo-controlled trial to reduce scores on the Tinnitus Handicap Inventory questionnaire, but not tinnitus loudness

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Phase (approx.) Cagrilintide dose Frequency Weeks 14 0.25 mg Once weekly Weeks 58 0.5 mg Once weekly Weeks 912 1.0 mg Once weekly Weeks 1316 1.7 mg Once weekly Week 17 onward 2.4 mg (max studied) Once weekly This step-wise schedule mirrors the titration used in cagrilintide and CagriSema studies ( Lau et al., Lancet 2021

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