In the case of water-soluble vitamins like B12, vitamin C, folic acid, and other B vitamins, some medically reviewed literature points to early morning as the optimal time to take them as they can be taken on an empty stomach, but more peer-reviewed research is needed to confirm this claim
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Was diagnosed with B12 deficiency last week
This is preferred to taking it at night before bedtime
Prescription B12 injections are more effective because they have higher bioavailability
You might be a good candidate if you have confirmed low B12 levels (from lab work), follow a strict vegan/vegetarian diet, have digestive issues reducing B12 absorption (e.g., after gastric surgery, or with conditions like Crohns), or experience chronic fatigue and other symptoms linked to B12 deficiency