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Crizotinib (PF-02341066) as a potent inhibitor of c-Met and ALK received approval for the treatment of patients with locally advanced or metastatic NSCLC that is ALK-positive in 2013 [70]

Data from large clinical trials also indicate long-term use may be effective and safe when medically necessary

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However, individual results vary, and effectiveness depends on factors such as adherence, lifestyle habits, dosage, and overall health

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Parenteral (non-oral) administration is faster and more efficient than oral supplements and is recommended for the initial or continued treatment of B12 deficiency