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Neither STEP 1 nor SUSTAIN 8 trials analysed the amount of non-fat lean tissue lost from the participants adipose tissue

Important considerations for calculating your protein needs: Use ideal or adjusted body weight rather than current weight for calculations Distribute protein across multiple meals (0.25-0.4 g/kg per meal) Prioritize protein intake early in the day when appetite may be better If you have chronic kidney disease (CKD stage 3 or higher), follow ADA/KDIGO guidelines of approximately 0.8 g/kg/day unless otherwise directed by your nephrologist Work with a registered dietitian for personalized recommendations These targets aim to preserve lean muscle mass, support metabolic rate, and optimize body composition changes during weight loss

Avoid consuming fruit on an empty stomach if you experience nausea, as the combination of natural sugars and delayed gastric emptying may exacerbate symptoms

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While both medications can cause gastrointestinal side effects , concurrent use remains possible under proper medical supervision