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PubMed Yeomans ND, et al

However, interpreting the health benefits of selenium against radiotherapy as the clinical validation of the radio-modulating activity of seleno-GPxs may be misleading, since selenium can manifest its beneficial effects through various mechanisms including but not limited to seleno-GPxs

doi: 10.1053/gast.2002.36019 424 LyteM

This may imply that the increased kidney RAS activation in diabetic mice noted by increased AGT, and fueled by ramipril-induced renin production, was redirected toward the non-classical RAS pathway (ACE2/Ang/Mas) (1-7) by ramipril with no differences between treatments

Moreover, certain assessments are limited by data availability, such as evaluations of CKD progress by measures of blood pressure, as these data are not widely available or reliable in real-world sources

Currie CJ, McEwan P, Peters JR, Patel TC, Dixon S