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Reduced expression of the E3 ubiquitin ligase Parkin ( Park2 ) has been documented in emphysematous lungs, and Parkin deficiency leads to impaired mitophagy, persistence of damaged mitochondria, and senescence-associated alterations in epithelial cells (Tsubouchi et al., 2018)

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Photo credit: Pixabay The United Kingdom is on the verge of becoming the worlds first country to implement a generational smoking ban