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Elevated homocysteine has been associated with skin changes including hyperpigmentation, and some research connects poor methylation status to inflammatory skin conditions

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In the central nervous system, glycine functions as a neurotransmitter with dual properties

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Current Evidence Level Stating the evidence tier precisely, without softening: Weighing the positive and negative studies The positive human evidence is real but structurally weak, and the weakness is specific: nearly all of it comes from a single investigator group