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By the 17th century, tobacco had reached the shores of Africa, Asia, and the Middle East, carried by traders and colonizers

This can be confusing for both patients and physicians to deduce underlying medical conditions

The effectiveness of LABA, LAMA and glucocorticoid treatment on LAR appeared to be retained in the CS-exposed model system

Factors with an overall unclear association according to the systematic literature review were not ranked but were given a low positive or negative weighting based on strength of evidence (taking into consideration the number of studies demonstrating consistent associations, geographic spread, and individual study characteristics)

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