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Mutations in mtDNA caused by ROS can further exacerbate mitochondrial dysfunction, creating a vicious cycle of oxidative stress and energy deficits (93)

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Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) was explicitly designed to address this: its oligopeptide structure is far smaller than traditional neuropeptides like BDNF or NGF, and early preclinical work suggested oral administration could deliver measurable CNS effects

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