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In conclusion, PDHA1 modulates epigenetic modifications by increasing intracellular acetyl-CoA levels, which, in turn, enhances H3K27ac acetylation and promotes the expression of SLC7A11

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Following manufacturer's instructions we treated cells with pure medium (TCS CellWorks, Buckingham, United Kingdom), or with VEGF as positive control (2 ng/ml), Suramin as negative control (20 uM) and BPC 157 in two different final concentrations (10 ug/ml and 2 ug/ml)