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Assays, biomarkers, and phenotypic endpoints Biochemical and transcriptional readouts ERR target-gene panels spanning fatty-acid uptake/-oxidation (Cpt1b, Acadl/Acadm), OXPHOS (Ndufs, Uqcrc, Cox), TCA (Cs, Idh), and mitochondrial biogenesis (Ppargc1a, Tfam) provide proximal pharmacodynamic evidence of receptor engagement

That is the peer-reviewed evidence base for dihexa's cognitive effects

However it should be noted that according to Stanley [168], over the past 40 years, there have been only two clear examples of disorders directly due carnitine deficiency that have provided evidence of unequivocal benefit from carnitine treatment

M., & Burris, T

For some, it rebounds beyond pre-treatment levels temporarily before normalizing

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