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Changes in Nicotine Dependence Among Smokers Using Electronic Cigarettes to Reduce Cigarette Smoking in a Randomized Controlled Trial Jessica Yingst, Xi Wang, Alexa Lopez, Alison Breland, Eric Soule, Andrew Barnes, Joanna Cohen, Megan Underwood, Melanie Crabtree, Jonathan Foulds Nicotine & Tobacco Research 9

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Since less than 20% of smokers who try ECs progress to using them daily 18,19 , our results indicate that smokers need to be properly informed about the difference in characteristics of EC use compared to tobacco cigarettes in order to avoid any initial disappointment which would discourage further use and compromise successful smoking substitution or lead to dual use of tobacco cigarettes and ECs