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However, direct cartilage injection of IGF-1 more effective than systemic elevation, and systemic growth hormone peptides produce modest IGF-1 increases (not pharmacological levels)

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Work from David Savages group showed that PLIN1 mutations from patients with lipodystrophies, which lack the C-terminus, fail to stabilize ABHD5 on LDs, resulting in greater basal lipolysis (137) and likely explains why these patients are unable to sequester FAs into TAGs