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In the zebrafish, ibuprofen administration at environmental concentrations (0.1-11 g/L) altered the antioxidant defense system and liver protein carbonylation, and increased blood vitellogenin-like protein levels and lactate dehydrogenase activity [35]

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Because that oxidative stress just got knocked down, and your mitochondria just said, "Thank you. Too much toxic stress on your mitochondria is going to prevent them from working